I have Jane Greenoff's Cross Stitch Designer, and I have Vista, and they work just fine together
Cross stitch designer annoys me sometimes, as Mabel said the "undo" function is unpredictable, but in general it's OK. I've used it to convert a painting to a chart, and to create a number of charts from scratch.
Interesting point - cross stitch designer won't give you any evenweave options. You can see what your design will look like stitched on aida, but not on evenweave; and there are no options for squashed stitches, only full or fractional stitches, and back stitch.
The program seems "unfinished", for lack of a better word, in a number of ways. If I'm writing a word using the pre-loaded alphabets, I have to open the alphabet new again for every letter. So, when I designed a sampler for my mother-in-law with the family surname on it, I had to open it eight times just to put the name in. That's frustrating. Also, it's meant to allow me to save motifs to the library, and it doesn't; or if it does, it's complicated to the point that I can't do it.
For the basics, it's definitely useable; but it's not always user-friendly. I have been thinking about replacing it with something more friendly, but I'll be careful to check that anything runs with vista!
3 out of 5.